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  Vol. 28, n. 1, 2010
  CONTENTS
COVER STORY
NEWS
ECONOMIC OVERVIEW
FINE CHEMICALS
FLOW CHEMISTRY
BIOCIDES
ANALYTICAL TECHNOLOGIES
CUSTOM SYNTHESIS
CATALYSIS
PROCESS DEVELOPMENT
METATHESIS
Novasep global solutions for the manufacture of synthetic molecules. More than a CMO…
Authors: Novasep Synthesis
Novasep develops, markets and operates innovative technologies to produce synthetic molecules and biomolecules from lab to industrial scale. We have developed a unique business model to meet the challenging manufacturing needs of the pharmaceutical, agrochemical, cosmetic, and fine chemicals industries for producing synthetic molecules.
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News

The chemical industry. Providing solutions in the face of challenges
Authors: Jourquin C. (Cefic, BELGIUM)
The entire European economy is facing challenging times ahead. We need to pull ourselves out of the recession, guarantee our global competitiveness and, in the longer term, reduce the carbon intensity of our economies. Indeed, a recent life cycle study of the chemical industry’s products by the icca and McKinsey, which has been verified by a third party, clearly demonstrates that for each tonne of CO 2 emitted by the Chemical Industry, the emission of two to three tonnes of CO 2 are avoided later thanks to the application of our products
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Batch chemical manufacturers buffeted but weathering economic storm
Authors: Brotherton L. (SOCMA, USA)
The recession has hurt all aspects of commerce, and the chemical industry is no exception. Batch and custom manufacturers have experienced a measurable reduction in demand, with some SOCMA members reporting sales losses of as much as 20-25 percent
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PRODUCT FOCUS - World largest collection of tangible building blocks and fragments for drug discovery
Authors: Krotko D., Chuprina A., Shivanyuk A., Tolmachev A. (Enamine, UKRAINE)
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Europe’s place within the global fine chemical industry
Authors: BRYANT R. (Brychem, UK)
It hardly needs stating that the last two years have been challenging ones for European economies. The speciality and fine chemical industry have been unable to escape its effects. According to Cefic (European Chemical Industry Council), the volume of production in the speciality chemical sector decreased by 3.8 percent in 2008 and is expected to drop by another 9.3 percent in 2009. The first half of 2009 appears to have been worse than the latter part of the year (Figure1) Cefic optimistically predicts that production will grow by 5.5 percent in 2010
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2,2,6,6-Tetraalkylpiperidine-N-oxyls and N-alkoxyamines (part I)
Authors: SCHÖNING K. (BASF, SWITZERLAND)
This review aims at demonstrating the enormous scope of 2,2,6,6-tetraalkylpiperidine N-O compounds (nitroxide radicals and N-alkoxyamines) both in academia and in industrial applications. Beyond classical TEMPO-catalysed oxidation reactions, these substances may for instance be applied as carbon radical scavengers, polymerisation initiators, spin labels, in materials science, biological processes, protein analytics, or for the stabilisation of polymers.
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PRODUCT FOCUS - Corning® Advanced-Flow™ glass reactors. Now it is simple to scale up production!
Authors: DANN E., SCHMIDT F., CHEVALIER B. (Corning, FRANCE)
Corning Incorporated, the world leader in specialty glass and ceramics, provides significant performance benefits to industrial chemical processing through its Advanced-Flow glass reactors — high-throughput, easily scalable glass reactors that can be customized to customers’ specific needs — enabling a cost-effective solution for a single reaction or a wide portfolio of reactions. Corning’s proprietary reactor technology increases the efficiency, scalability, and quality of chemical processing — all while reducing environmental impact, performance variability and cost.
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Successful 1st Symposium on Continuous Flow Reactor Technology for Industrial
Authors: DE MARIA G.
Chimica Oggi/Chemistry Today organized a first symposium on “Continuous Flow Reactor Technology for Industrial Applications” on October 12th, one day before CPhI, in Madrid. In coordination with the symposium sponsor, Corning SAS, Chimica Oggi/Chemistry Today brought together seventeen speakers from industry and academia to discuss the most recent applications and experiences from the world of continuous flow chemistry
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COMPANY PROFILE - Saltigo - our experience,

COMPANY PROFILE - Saltigo: our experience, your way forward
Authors: Jones T. (Saltigo, GERMANY)
LANXESS´s subsidiary Saltigo is dedicated to custom synthesis and manufacturing services for small molecules and serves the needs of customers in the Pharma, Agro and Specialty Chemical industries. Saltigo is committed to supporting its customers throughout the entire life cycle of their products - according to national and international regulations and to the principles of sustainable development
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Antimicrobial surfaces: addressing the intended application
Authors: VERRAN J. (Manchester Metropolitan Univ, UK)
The article considers some of the limitations of “hygienic” antimicrobial surfaces used in the environment, particularly in terms of validating their effectiveness at point of use. Although it is often simple to visualise in vitro the diffusion of an antimicrobial from a surface, via the resultant inhibition of target organisms, it is less easy to demonstrate antimicrobial properties of a surface that is exposed to the air.
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COMPANY PROFILE - Aesica Pharmaceuticals

“Seeing” the chemicals in pharmaceutical tablets with NI R chemical imaging
Authors: SANDO G. , DUBOIS J. (Malvern Instruments, USA)
Product and process understanding in the pharmaceutical industry have increased in recent years with the advent of new technologies that gave access to new information. Near infrared chemical imaging is an advanced form of NI R spectroscopy, where a collection of tens of thousands of spectra are acquired at once using a NI R array detector to give insight into the chemical composition of powders and tablets.
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INDUSTRY PERSPECTIVE - High speed chromatography results New tools for faster chromatography workflows
Authors: McLEOD F. (Softron, GERMANY)
In today’s laboratories there are many steps between receiving a sample for analysis and producing the final results. These include creating and running the sequence, integrating the chromatograms, creating calibration curves, and calculating and reporting the results. Many of these steps involve manual processes which require a high degree of training, and are often error prone due to the large amounts of data that are handled
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INDUSTRY PERSPECTIVE - Economically and ecologically optimized contract synthesis of pharmaceuticals. Innovative processes reduce costs and protect the environment
Authors: Von Dem Bruch K. (Saltigo, GERMANY)
Custom manufacturing is more than just the reliable and on-time delivery of products. The choice of the synthetic route as well as process development and optimization are other important factors for success. It is not just the yield, product quality and reaction times that can be optimized in this way. It is also possible to minimize the amounts of waste produced and the energy requirement and consequently to follow reaction paths which are economically and ecologically equally attractive
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Recent advances in the understanding of the direct conversion of soot and NO on Fe2O3 catalyst in diesel exhaust
Authors: REICHERT D., BOCKHORN H., KURETI S. (Karlsruhe Inst of Technology, GERMANY)
This article reviews the fundamentals of the catalytic reaction of soot and NO in diesel exhaust to form N2 and CO2 focussing on the model catalyst Fe2O3. It was found out that the soot/NO reaction is a side reaction of the soot/O2 conversion, in which the Fe2O3 catalyst acts as oxygen pump transferring oxygen from the gas-phase via its surface to the soot
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Manufacturing efficiency by modular multipurpose plants. Combining batch flexibility with continuous flow chemistry performance
Authors: KIRSCHNECK D. (Microinnova Engineering, AUSTRIA)
This work presents a new innovative concept, how basic manufacturing needs of small and medium scale manufacturing tasks can be moved to a higher level of efficiency. The basic idea of the concept is to combine the long time known performance of continuous processing with the flexibility of today’s common batch synthesis. The concept uses a modularized continuous plant concept, where the needed flexibility is provided by first rearrangement of the processing modules and second modularity within each module to adjust it according to the needs of each chemical reaction. This gives the possibility to reach a continuous processing performance by means of a flexible multi purpose plant
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Development of alkyne metathesis catalysts. It’s a game of give and take
Authors: TAMM M., WU X. (Technische Univ Braunschweig, GERMANY)
New Schrock type tungsten alkylidyne complexes were designed and synthesized through high and low oxidation state routes. In particular, the tungsten alkylidyne complexes 2 and 4 bearing the 1,3-di-tertbutylimidazolin- 2-iminato group (ImtBuN) exhibit very high catalytic activities in alkyne metathesis reactions such as alkyne cross metathesis and ring-closing alkyne metathesis
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